What question did this study set out to answer?

Investigate synthetic methodologies to achieve dual ring fusion (bisannelation) on aromatic substrates using bis-aryne equivalents.

October 1, 1980Journal of the American Chemical Society

Bisannelation of arenes with bis-aryne equivalents

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Authors

HHHarold HartGifu Pharmaceutical University CLChung-Yin LaiHong Kong Baptist University GNGodson C. NwokoguHampton University

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Implication

Synthetic chemistry study demonstrates the bisannelation of arenes using bis-aryne equivalents, highlighting a direct route for constructing complex polycyclic aromatic systems.

Key Points

Investigate synthetic methodologies to achieve dual ring fusion (bisannelation) on aromatic substrates using bis-aryne equivalents.
Generated reactive bis-aryne equivalents as intermediates in cycloaddition reactions with arene substrates.
Evaluated the efficiency and regiochemical outcomes of dual annelation onto aromatic cores.
Successfully demonstrated the bisannelation of arene systems to yield extended polycyclic aromatic frameworks.
Established a versatile synthetic approach for introducing two fused rings in tandem via bis-aryne intermediate equivalents.

Cite This Study

Hart et al. (1980) studied this question.

synapsesocial.com/papers/6a90fccb17bbbfe73e745266 https://doi.org/10.1021/ja00541a085

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Implication

Synthetic chemistry study demonstrates the bisannelation of arenes using bis-aryne equivalents, highlighting a direct route for constructing complex polycyclic aromatic systems.

Bisannelation of arenes with bis-aryne equivalents

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Implication

Key Points

Cite This Study

Bisannelation of arenes with bis-aryne equivalents

Discussion

Member takes

Implication

Key Points

Cite This Study

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