Mechanistic study uncovers paracrine-induced apoptosis in uninfected bystander cells, suggesting an alternative pathway for virus-mediated tissue damage.
It is well accepted that herpesviruses suppress the apoptosis of host cells via various strategies to ensure sustained viral replication during infection. However, a recentin vivostudy reported the apoptosis of remote uninfected cells during GaHV-1 infection. The mechanism and the biological meaning of this unexpected herpesvirus-host interaction are unclear. This study uncovers the mechanisms of herpesvirus-triggered apoptosis in uninfected cells and may also contribute to a mechanistic illustration of paracrine-regulated apoptosis induced by other viruses in uninfected host cells.
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Li et al. (2018) studied this question.
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