Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study
Key result
CCTA perivascular fat attenuation index stratifies cardiac risk associated with high-risk plaques.
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Discussion
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Key expert perspectives
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“This new technology may prove transformative for primary and secondary prevention. For the first time we have a set of biomarkers, derived from a routine test that is already used in everyday clinical practice, that measures what we call the 'residual cardiovascular risk', currently missed by all risk scores and non-invasive tests. Knowing who is at increased risk for a heart attack could allow us to intervene early enough to prevent it. I expect these biomarkers to become an essential part of standard CT coronary angiography reporting in the coming years.”
“The FAI is a powerful, novel technology for cardiovascular disease risk stratification. It has striking prognostic value for cardiac death and nonfatal MI over and above other risk scores and state-of-the-art interpretation of coronary CT angiography.”
“This is an exciting new technology which has the potential for providing a simple, non-invasive answer to detect patients at risk for future fatal heart attacks. More importantly, it highlights the incredible value of cross-continent collaboration to validate the findings in different populations.”
Implication
Observational cohort study reveals that perivascular fat attenuation stratifies cardiac risk in suspected coronary artery disease, highlighting enhanced imaging-based risk assessment.
Key Points
- To evaluate whether the perivascular fat attenuation index improves cardiac risk stratification in patients with high-risk coronary plaques identified by coronary computed tomography angiography.
- Evaluated patients undergoing coronary computed tomography angiography for suspected coronary artery disease within the CRISP-CT study framework.
- Assessed coronary CTA parameters including luminal stenosis, distinct high-risk plaque characteristics, and perivascular fat attenuation index measurements.
- Coronary CTA characterized specific high-risk plaque features that were associated with an increased risk of adverse cardiovascular outcomes beyond luminal stenosis.
- Perivascular fat attenuation index analysis provided additional risk stratification among patients presenting with vulnerable, high-risk plaque morphology.
Cite This Study
Oikonomou et al. (2020) studied this question. Perivascular fat attenuation index on coronary computed tomography angiography stratifies the cardiac risk associated with high-risk plaques.