What does this research mean for the field?

Reentrant ventricular excitation in post-myocardial infarction hearts consistently occurs in a figure 8 configuration regardless of anatomical localization or whether it is spontaneous or induced. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the electrophysiological mechanisms and anatomical pathways distinguishing spontaneous from induced reentrant ventricular excitation in post-myocardial infarction canine models.

August 28, 2026Journal of the American College of CardiologyOpen Access

Reentrant ventricular arrhythmias in the late myocardial infarction period. 12. Spontaneous versus induced reentry and intramural versus epicardial circuits

Q: What is the clinical evidence from this study?

Study design: Other. Population: Myocardial infarction (n=4). Intervention: Programmed premature stimulation vs. Spontaneous rhythm. Primary outcome: Configuration of reentrant excitation circuits.

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Key result

Induced and spontaneous post-MI reentrant excitation always form a figure-8 configuration.

Comparison

Spontaneous reentry vs programmed premature stimulation-induced reentry

Design

Animal experimental study

Authors

NENabil El‐SherifElectrophysiology WGWilliam B. GoughUCB Pharma (Belgium)RZRobert H. ZeilerState University of New York

Discussion

Member takes

Implication

The figure 8 model may be the common model of reentry in the mammalian heart, regardless of circuit location or initiation mechanism.

Key Points

To investigate the electrophysiological mechanisms and anatomical pathways distinguishing spontaneous from induced reentrant ventricular excitation in post-myocardial infarction canine models.
Evaluated 4 canine models 1 to 5 days after one-stage ligation of the left anterior descending coronary artery.
Mapped and analyzed cardiac electrical activity during regular sinus/atrial rhythms and programmed premature electrical stimulation across epicardial and intramural septal regions.
Spontaneous reentrant tachycardias were initiated by tachycardia-dependent Wenckebach conduction patterns in potentially reentrant pathways, generating both manifest and concealed extrasystolic rhythms.
Programmed premature stimulation induced reentrant circuits at markedly shorter cycle lengths that differed anatomically from spontaneous circuits, including intramural pathways near patchy septal infarctions.
All observed reentrant circuits consistently formed a figure 8 configuration regardless of location (epicardial or intramural), circuit dimensions, or initiation mode (spontaneous vs. induced).

Structured PICO

Population

Experimental study in dogs 1 to 5 days post-myocardial infarction to evaluate the mechanisms and configurations of spontaneous versus induced reentrant ventricular arrhythmias.

Intervention

Programmed premature stimulation

Comparator

Spontaneous regular sinus or atrial rhythm

Outcome

Mechanism and configuration of reentrant excitation circuitssurrogate

The figure 8 model may be the common model of reentry in the mammalian heart, regardless of circuit location or initiation mechanism.

Cite This Study

El‐Sherif et al. (1985) studied Myocardial infarction (n=4). Programmed premature stimulation vs. Spontaneous rhythm was evaluated on Configuration of reentrant excitation circuits. Reentrant excitation in the post-myocardial infarction period always occurred in a figure 8 configuration, regardless of whether it was spontaneous or induced by programmed premature stimulation.

synapsesocial.com/papers/6a90fe1a73d671a805e3bb21 https://doi.org/10.1016/s0735-1097(85)80263-1

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Reentrant ventricular arrhythmias in the late myocardial infarction period. 12. Spontaneous versus induced reentry and intramural versus epicardial circuits

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Reentrant ventricular arrhythmias in the late myocardial infarction period. 12. Spontaneous versus induced reentry and intramural versus epicardial circuits

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider