Why the study?
Inflammation is crucial in atherosclerosis, and summarizing data on inflammatory biomarkers is needed to understand PAD pathophysiology and identify useful markers for monitoring outcomes.
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This review highlights the role of inflammatory biomarkers in the pathophysiology and outcome monitoring of peripheral arterial disease.
Peripheral arterial disease (PAD) is an atherosclerotic disease closely associated with high morbidity and mortality in cardiac events. Inflammation is crucial in atherosclerosis both at triggering and in progression. Numerous inflammatory biomarkers (cytokines, matrix metalloproteinases (MMPs), selectin, intracellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM) C-reactive protein (CRP), fibrinogen) have been measured in atherosclerotic diseases including PAD. This paper summarizes the data on the inflammatory biomarkers for PAD pathophysiology and highlights the most useful markers in monitoring PAD outcomes.
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Signorelli et al. (2019) studied this question.
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