Editorial: Structure-function metrology of proteins

This is the authors' abstract. We don't add key points for this paper.

The importance of a protein's structure to its function is beyond doubt. The Protein Databank (PDB) What is becoming increasingly clear, however, is that the structure-function paradigm of proteins is more nuanced than a collection of fixed, static 3D structures. Data from a wide range of measures have revealed varying degrees of conformational flexibility and disorder (e.g., This picture serves to illustrate the importance to protein metrology of using a range of different measurements, but it also reflects a complex measurement landscape. The increased use of proteins in the Life Sciences, Health, and Food industries complicates the picture further. Which measurements, or combination thereof, are required to demonstrate regulatory compliance (e.g., EU, 2011; EU, 2017) for a given application? One size is unlikely to fit all.