What question did this study set out to answer?

To determine whether clinical parameters, viral serotypes, cytokines, and rotavirus-specific antibodies are associated with the progression from acute to persistent diarrhea after rotavirus infection.

September 1, 1999Clinical and Diagnostic Laboratory ImmunologyOpen Access

Immune Response of Children Who Develop Persistent Diarrhea following Rotavirus Infection

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To determine whether clinical parameters, viral serotypes, cytokines, and rotavirus-specific antibodies are associated with the progression from acute to persistent diarrhea after rotavirus infection.
Conducted a prospective study enrolling 149 Bangladeshi children with watery diarrhea (6–8 days duration) alongside 13 uninfected controls.
Identified 29 children with rotavirus alone, classifying them into acute diarrhea (resolved within 14 days, n=19) or persistent diarrhea (>14 days, n=10).
Measured plasma and fecal cytokine levels (IL-10, TNF-alpha, IFN-gamma) and rotavirus-specific IgG and IgA titers on enrollment and at persistence.
Plasma IFN-gamma concentrations were significantly higher in children developing persistent diarrhea than in those with acute diarrhea (P = 0.008) or uninfected controls (P = 0.001).
Plasma IL-10 and TNF-alpha were increased in children with diarrhea relative to controls but showed no significant differences between the acute and persistent diarrhea groups.
Plasma rotavirus-specific IgG was higher in uninfected controls than in acute (P < 0.001) or persistent cases (P = 0.024), whereas neither IgG nor IgA distinguished acute from persistent diarrhea.

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Implication

Prospective cohort study reveals elevated plasma interferon-gamma predicts persistent diarrhea in rotavirus-infected children, indicating an altered systemic immune response.

Cite This Study

Azim et al. (1999) studied this question.

synapsesocial.com/papers/6a910119ceede2f58ae1b09b https://doi.org/10.1128/cdli.6.5.690-695.1999

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Implication

Prospective cohort study reveals elevated plasma interferon-gamma predicts persistent diarrhea in rotavirus-infected children, indicating an altered systemic immune response.

Immune Response of Children Who Develop Persistent Diarrhea following Rotavirus Infection

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Discussion

Implication

Cite This Study

Immune Response of Children Who Develop Persistent Diarrhea following Rotavirus Infection

Key Points

Discussion

Implication

Cite This Study

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