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The existence of anoxia during anesthesia is indicated clinically by the frequent appearance of cyanosis and experimentally by the observation of a diminished oxygenation1of the blood and oxygen consumption.2The deleterious effects of anoxia have been emphasized by Haldane3and Barcroft.4The latter author has classified the anoxias into three groups and discussed the relative dangers of each. Lunsgaard and Van Slyke5have shown that cyanosis does not give adequate clinical indications of the degree of anoxia, since it depends on the presence of a certain quantity of reduced hemoglobin in the blood and not on the relative proportions of reduced and oxygenated blood. This sign may occur in a person with polyglobulism with a small alteration in the oxygen saturation, whereas it could not appear in an anemic person except in the presence of advanced asphyxia. Therefore, it is possible for a subclinical
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John Shaw (1937) studied this question.
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