Population
Dahl salt-sensitive male and female rats fed an 8% NaCl diet for 4 weeks (hypertensive model)
Comparison
17beta-Estradiol vs 17alpha-estradiol and untreated rings/male rats
Design
Preclinical
Authors
Loading...
May indicate sex-specific vascular effects of estradiol in hypertensive rat models; leaves open translation to human hypertension.
17beta-Estradiol rapidly antagonizes increases in vascular tone in hypertensive female rats by enhancing NO-dependent relaxation and suppressing EDCF-mediated mechanisms.
Zhang et al. (2002) studied this question.