Population
Guinea-pig isolated tracheal smooth muscle
Design
Preclinical
Authors
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Suggests isoprenaline relaxes airway muscle via Ca2+ influx inhibition; leaves open translation to human disease.
Isoprenaline induces relaxation in guinea-pig tracheal muscle likely by inhibiting a receptor-operated pathway for Ca2+ influx rather than activating TEA-sensitive Ca2+-dependent K+ channels.
Ito et al. (1995) studied this question.
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