What question did this study set out to answer?

To evaluate the immunogenicity, safety, and therapeutic potential of DNA plasmids expressing HIV-1 genes in preclinical models and human clinical trials.

November 1, 1998VaccineOpen Access

DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans

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Authors

KUKenneth E. UgenThe Wistar Institute SNSusan B. NylandUniversity of Virginia JBJean BoyerCelsion (United States)

Discussion

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Implication

Phase I clinical trials demonstrate immune response boosting and favorable safety in humans, suggesting therapeutic potential for HIV-1 DNA vaccines.

Key Points

To evaluate the immunogenicity, safety, and therapeutic potential of DNA plasmids expressing HIV-1 genes in preclinical models and human clinical trials.
Intramuscular administration of DNA plasmid constructs expressing HIV-1 genes evaluated in chimpanzees and human participants.
Evaluation of protective efficacy in naive chimpanzees challenged with heterologous HIV-1 and therapeutic efficacy in HIV-1-infected chimpanzees.
Phase I therapeutic clinical trials assessing safety profiles and immune potentiation in human participants.
Intramuscular vaccination lowered HIV-1 viral load in infected chimpanzees and conferred protection against heterologous HIV-1 challenge in naive chimpanzees.
Phase I human trials demonstrated a favorable safety profile with marked immunological potentiation and boosted anti-HIV-1 immune responses.

Cite This Study

Ugen et al. (1998) studied this question.

synapsesocial.com/papers/6a910c19c39ca0eda1830a53 https://doi.org/10.1016/s0264-410x(98)00180-7

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Implication

Phase I clinical trials demonstrate immune response boosting and favorable safety in humans, suggesting therapeutic potential for HIV-1 DNA vaccines.

DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans

Discussion

Member takes

Implication

Key Points

Cite This Study

DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans

Discussion

Member takes

Implication

Key Points

Cite This Study

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