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December 9, 2017Blood Coagulation & Fibrinolysis

In patients under double antiplatelet therapy, the time-to-gel point was significantly longer (345 s vs 180 s, P=0.039) and steady clot viscosity was significantly lower (10 cP vs 16 cP, P=0.012) compared to patients free from major antiplatelet agents.

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Why the study?

Does double antiplatelet therapy affect shear-dependent blood activation and clot formation in an ex-vivo model?

Population

28 patients

Comparison

Ex-vivo blood testing using a cone-on-plate… vs Patients free from major antiplatelet agents vs…

Design

Preclinical

Authors

MRMarco RanucciMRMatteo RanucciEBEkaterina Baryshnikova

Discussion

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Overview

Model may enable activator-free shear testing in vitro; leaves open validation in larger cohorts before any clinical use.

Structured PICO

Does double antiplatelet therapy affect shear-dependent blood activation and clot formation in an ex-vivo model?

P
Population
28 patients (22 free from anticoagulants and major antiplatelet agents, and 6 under the effects of P2Y12 platelet inhibitors)
I
Intervention
Ex-vivo blood testing using a cone-on-plate viscosimeter at a shear rate of 100 s-1
C
Comparator
Patients free from major antiplatelet agents vs. patients under double antiplatelet therapy
O
Outcome
Changes in blood viscosity characterized by a time-to-gel point (TGP), a maximum clot viscosity, and a steady clot viscosity (SCV)surrogate

An ex-vivo model of shear-dependent blood activation demonstrates that double antiplatelet therapy significantly delays clot formation and reduces clot viscosity without requiring artificial activators.

Cite This Study

Ranucci et al. (2017) studied this question.

synapsesocial.com/papers/6a910d06f69e67dea4361995https://doi.org/10.1097/mbc.0000000000000688
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The rate of platelet activation determines thrombus size and structure at arterial shear2023 · 14 citations
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  4. 4Shear stress-induced platelet activation enhances blood coagulation more than adenosine diphosphate-induced activation2025
  5. 5Quantification of Shear‐Induced Platelet Activation: High Shear Stresses for Short Exposure Time2015 · 88 citations