Why the study?
How does balloon mitral valvulotomy affect plasma ANF and cGMP levels in patients with mitral stenosis, and how does atrial fibrillation influence this response?
How does balloon mitral valvulotomy affect plasma ANF and cGMP levels in patients with mitral stenosis, and how does atrial fibrillation influence this response?
In patients with mitral stenosis, ANF secretion increases depending on LA pressure in sinus rhythm, but this appropriate response to LA pressure changes is lost in patients with atrial fibrillation.
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Blunted ANF response to LA pressure in AF with mitral stenosis; leaves open whether rhythm control restores coupling or alters post-valvulotomy hemodynamics.
Dussaule et al. (1988) studied this question.
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