Reaction of Lithioamines with Alkyl Halides: A Convenient Direct Synthesis of N-Alkylaminopyridines

-Alkylation of aromatic and heteroaromatic amines con-stitutes an important synthetic strategy for new C-N bondformation. Aromatic and heteroaromatic amines are lessnucleophilic when compared to aliphatic amines and alkyl-ation of these amines requires activated halides, alcohols,aldehydes and ketonesor expensive metal catalysts toundergo the C-N bond formation process.