Population
tsA201 cells transfected with twelve cysteine- and/or histidine-replacement mutants of the human skeletal…
Comparison
External application of 1 mM Zn2+ or diethyl… vs Wild type (WT) channels
Design
Preclinical
Authors
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Should not yet change clinical practice in channelopathies; leaves open whether these cysteines are viable therapeutic targets in hClC-1.
Cysteines C546, C242, and C254 are identified as likely targets for Zn2+ binding and blockade of the human skeletal muscle chloride channel hClC-1.
Kürz et al. (1999) studied this question.
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