Population
Isolated cat papillary muscle preparations
Comparison
Hypoxia (oxygen deprivation) vs Baseline/normoxia and altered buffer calcium
Design
Preclinical
Authors
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Hypoxia asymmetrically impairs isolated cardiac muscle mechanics; leaves open translation to intact hearts or clinical hypoxia.
Hypoxia reversibly and asymmetrically depresses the mechanical capabilities of heart muscle, specifically decreasing maximum unloaded shortening velocity (Vmax).
Henderson et al. (1973) studied this question.