Is antibiotic resistance a problem in the treatment of ophthalmic infections?

Antibiotic resistance is a world-wide problem of systemic medicine, but it appears to be less problematic in the treatment of ophthalmic infections. The use of topical administration and intraocular injection of antibiotics provides very high antibiotic concentrations in the ocular tissues. These high concentrations are effective in treating bacteria that are deemed resistant using standard interpretations of susceptibility. Although in vitro bacterial resistance, based on serum standard interpretation, is reported for ocular bacteria, these isolates are generally not spread from patient-to-patient and there are antibiotics available to effectively treat and overcome the false resistance.