Are favorite molecules of endometrial receptivity still in favor?

The synchronized efforts of a receptive endometrium and an appropriately developed embryo are prerequisites for successful embryonic implantation. The search for the potential informative marker of uterine receptivity to embryo implantation is ongoing. This review summarizes the current knowledge gained from knockout mouse models with infertile phenotype, expression profiles of corresponding genes in human endometrium in relation to its reproductive potential and correlation of those data with information from microarray studies of the human endometrium in several conditions. Discrepancies in data generated by one-by-one versus a whole-genome approach exist and can be explained in several ways. Nevertheless, the complexity of changes resulting in a receptive state during the secretory phase of the menstrual cycle can be documented better by studying the changes on the level of the whole genome.