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Obscure-etiology heart diseases continue to defy classification; leaves open the need for refined etiologic frameworks in both practice and research.
EXTRAORDINARY advances have been made in the last fifty years in the diagnosis and classification of diseases of the heart. However, a small group difficult to fit into any well defined category remains, and each year scattered reports of isolated cases of obscure etiology appear.1 2 3 4 5 6 7 8 9 10 11 These cases are often from special institutions restricted in age and sex distribution (such as children's and veterans' hospitals), and since the available material is at best diffuse and difficult to assemble, we have reviewed the total experience at the Massachusetts General Hospital during the past twenty-five years (10,000 autopsies) on heart disease of obscure . . .
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Thomas et al. (1954) studied this question.
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