Coronary artery thrombosis is the most common non-atherosclerotic cause of myocardial infarction in this cohort and may respond favorably to thrombolytic treatment.
May support thrombolysis for thrombosis-related non-atherosclerotic MI; hypothesis-generating and requires prospective validation.
We routinely treat young patients with myocardial infarction with no conventional risk factors for atherosclerosis other than smoking. Angiogram in such patients usually shows either a recanalized artery or evidence of thrombus. We aimed at deciphering non atherosclerotic causes of ischemia at our centre. We serially analyzed 1500 diagnostic angiograms done at our center over a period of one year, with all patients above eighteen years of age. A retrospective analysis of presentation, risk factors and treatment and outcome (when available) was done. Coronary artery thrombosis was most common cause ( 5 patients), followed by coronary artery dissection (3) and coronary artery embolisation (2) patients. Takayasu arteritis and anamoulus origin of coronary artery were other causes. Our study suggests that coronary artery thrombosis is most common non atherosclerotic cause of myocardial infarction and may respond favorably to thrombolytic treatment.
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Deepak et al. (2012) studied this question.
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