Key result
A 31-year-old male without traditional cardiovascular risk factors developed severe coronary artery disease and acute myocardial infarction, potentially driven by accelerated atherosclerosis from prolonged mental stress.
Case Report (n=1)
This case highlights the occurrence of severe left main coronary artery disease in a young patient without traditional risk factors, suggesting a potential role for prolonged mental stress in accelerated atherosclerosis.
Mental stress may warrant consideration in young MI without risks; single case leaves open causality and needs prospective validation.
We present the case of a 31-year-old patient, without cardiovascular risk factors, without significant pathological or family history of cardiovascular disease, who was diagnosed with severe coronary artery disease, left main bifurcation localization, which required surgical coronary revascularization. The angiographic and intraoperative aspect excluded the most common causes of non-atherosclerotic causes of coronary lesions. Vasculitis was another possible etiology but was also excluded based on the normal clinical examination, negative inflammation markers, lack of diffuse vascular impairment, TPHA and negative VDRL. Prolonged mental stress can lead to accelerated progression of atherosclerosis by inducing endothelial dysfunction, our patient describing a “burnout syndrome” in the last few months. The particularity of the presented case is the severe coronary artery disease in a young patient without discovering the main etiology of the advanced atherosclerotic process.
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Nedelcu et al. (2020) conducted a case report in Acute myocardial infarction (n=1). Prolonged mental stress (burnout syndrome) was evaluated. A 31-year-old male without traditional cardiovascular risk factors developed severe coronary artery disease and acute myocardial infarction, potentially driven by accelerated atherosclerosis from prolonged mental stress.
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