The CACNA2D2 gene encodes a functional auxiliary subunit of voltage-gated calcium channels that significantly increases peak calcium currents and may act as a tumor suppressor gene.
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Differential amplification of Ca(2+) currents may alter excitability in excitable cells; hypothesis-generating for CACNA2D2 in channelopathies.
Gao et al. (2000) studied this question.
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