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Infections of man byMycobacterium uleranscause extensive necrosis of skin and subcutaneous tissue. Although the mechanism of this necrosis has not been determined, in this study we have shown that cultures ofMulcerans in vitro produce a toxin that, when inoculated into guinea pig skin, causes inflammation and necrosis. The changes in the guinea pig skin resemble those seen in naturally occurring human infections. This toxin is present in the culture filtrate, in the cytoplasmic fluid, and in the particulate fraction. It is heat-stable, active following ether extraction, and the only known toxin produced by a mycobacterium.
Richard E. Krieg (1974) studied this question.