Why the study?
Does exposure to particulate matter-associated zinc cause cardiac injury in rats?
Population
12- to 14-week-old male Wistar Kyoto rats
Comparison
Intratracheal exposure to whole-combustion… vs Intratracheal exposure to saline or PM having no…
Design
Preclinical
Follow-up
8 or 16 weeks
Authors
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Zinc in PM may contribute to cardiac injury in rats; hypothesis-generating for human relevance, with no clinical implications yet.
Does exposure to particulate matter-associated zinc cause cardiac injury in rats?
Water-soluble particulate matter-associated zinc may be a causal component in PM-induced cardiac injury, as evidenced by mitochondrial DNA damage and altered gene expression in a rat model.
Kodavanti et al. (2007) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: