preleukemic situation as virtually all CLL patients appear to have a preleukemic phase of monoclonal B-cell lymphocytosis. 20 Understanding which genes are involved in the transition of monoclonal B-cell lymphocytosis into overt CLL and investigating to what extent antigen stimulation and an inflammatory proactive microenvironment favor this transition may provide a clue to many unanswered questions.
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Berndt et al. (2011) studied this question.
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