What question did this study set out to answer?

To evaluate whether the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism relates to carotid atherosclerosis in a low-risk population.

December 1, 1995Journal of Hypertension

Angiotensin converting enzyme gene polymorphism and carotid atherosclerosis in a low-risk population

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Why the study?

Is ACE I/D polymorphism associated with carotid atherosclerosis in a low-risk population?

Population

240 low-risk patients, mean age 53.6 +/- 7 years

Comparison

ACE I/D polymorphism (DD, ID, II genotypes) vs Comparison among ACE genotypes

Design

Cross-sectional

Authors

RCRoberto CataliniMarche Polytechnic University RSRiccardo SarzaniMarche Polytechnic University SSS SturbiniALK-Abelló (Italy)

Discussion

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Implication

ACE I/D polymorphism was not associated with carotid atherosclerosis in low-risk adults; leaves open differential effects by vascular bed or risk stratum.

Key Points

To evaluate whether the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism relates to carotid atherosclerosis in a low-risk population.
Enrolled 240 low-risk patients (mean age 53.6 ± 7 years) categorized by carotid intimal-medial thickness into normal (<1.0 mm; n=47), thickened (1.0–1.3 mm; n=56), or atherosclerotic plaque (>1.3 mm; n=137) groups.
Determined leukocyte ACE I/D genotypes using polymerase chain reaction and quantified plasma ACE, renin activity, and aldosterone levels.
Genotype distributions, allele frequencies, and humoral parameters did not differ significantly among normal, thickened, and plaque groups.
Mean carotid intimal-medial thickness showed no significant differences across ACE genotypes.
Plasma ACE concentrations were significantly higher in DD (14.27 ± 5.05 IU/ml) and ID (12.70 ± 4.31 IU/ml) genotypes compared with the II genotype (8.04 ± 3.45 IU/ml).

Structured PICO

Is ACE I/D polymorphism associated with carotid atherosclerosis in a low-risk population?

Population

240 low-risk patients, mean age 53.6 +/- 7 years

Intervention

ACE I/D polymorphism (DD, ID, II genotypes)

Comparator

Comparison among ACE genotypes

Outcome

Carotid atherosclerosis evaluated by ultrasonography (intimal-medial thickness)surrogate

ACE I/D polymorphism does not appear to be associated with carotid atherosclerosis in low-risk populations, despite its known association with coronary disease.

Limitations

small sample size

Cite This Study

Catalini et al. (1995) studied this question.

synapsesocial.com/papers/6a911e4ecd6c08c0eacaf2f0 https://doi.org/10.1097/00004872-199512010-00015

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Implication

ACE I/D polymorphism was not associated with carotid atherosclerosis in low-risk adults; leaves open differential effects by vascular bed or risk stratum.

Angiotensin converting enzyme gene polymorphism and carotid atherosclerosis in a low-risk population

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Angiotensin converting enzyme gene polymorphism and carotid atherosclerosis in a low-risk population

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider