Why the study?
The rs4340ID polymorphism of ACE correlates with serum ACE levels in many cancers, but its association and interaction with addiction status in older patients with lung cancer needed evaluation.
Does the ACE rs4340 ID polymorphism and tobacco consumption increase the risk of lung cancer in older patients?
Does the ACE rs4340 ID polymorphism and tobacco consumption increase the risk of lung cancer in older patients?
The ACE rs4340 II genotype and its interaction with tobacco consumption significantly increase the risk of lung cancer in older patients from North India.
II genotype may raise lung cancer risk in older North Indians, especially with tobacco; leaves open validation before any clinical consideration.
BACKGROUND: rs4340ID polymorphism of angiotensin-converting enzyme (ACE) correlates with serum ACE levels in many known cancers. This study analyzed ACE rs4340 ID polymorphism in lung cancer (LC) in older patients of North India and correlated it with addiction status. METHODS: The study enrolled all subjects aged 60 years and above with 154 LC and 205 healthy controls. Genotyping was done by polymerase chain reaction (PCR) and validated by sequencing of 10% of the sample. Statistical analysis was done by SPSS Statistics 21. RESULTS: Genotype II was observed to have a significant 2.21-fold increased risk of LC as compared to the DD genotype and 3.43-folds enhanced risk with interaction of I allele with tobacco consumption habits as compared to D allele in LC was seen. CONCLUSION: The risk of LC was higher with II genotype as compared to DD genotype. Interactive effect showed that I allele with tobacco habits may increase the risk of LC.
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Banerjee et al. (2021) studied this question.
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