Key result
ACE A-240T allele linked to ~20% higher lung cancer risk.
Why the study?
The gene encoding angiotensin converting enzyme (ACE) is a promising candidate for lung cancer, but the association of its polymorphisms with lung cancer risk in Chinese people was unclear.
Are ACE gene polymorphisms associated with an increased risk of lung cancer in a Chinese population?
Case-Control (n=1,286)
Are ACE gene polymorphisms associated with an increased risk of lung cancer in a Chinese population?
Odds Ratio: 1.2 (95% CI 1.02–1.42)
p-value: p=0.027
The ACE gene A-240T polymorphism may serve as a genetic marker for lung cancer development in Chinese populations.
A-240T variant may signal higher lung cancer susceptibility in Chinese adults; leaves open any role for ACE genotyping in risk assessment or prevention.
BACKGROUND AND OBJECTIVE: The gene encoding angiotensin converting enzyme (ACE) is a promising candidate for lung cancer. We aimed to assess three well-characterized polymorphisms of the ACE gene (A-240T, I/D, A2350G) and lung cancer in Chinese people, and complete a meta-analysis of the association of I/D polymorphism with lung cancer. METHODS AND RESULTS: In our case-control study, a total of 684 patients with lung cancer and 602 age-matched controls were recruited. Genotyping was performed using polymerase chain reaction (PCR) and ligase detection reactions (LDR) techniques. Single-locus analysis indicated that carriers of the A-240T allele had a significantly increased risk for lung cancer under additive (odds ratio (OR)=1.2; 95% confidence interval (CI): 1.02-1.42; P=0.027) and recessive (OR=1.8; 95% CI: 1.24-2.63; P=0.002) models, and that DD genotype carriers were 1.97 times more likely to develop lung cancer (95% CI: 1.25-3.11; P=0.004) compared with those with the I allele under the recessive model. However, no significance was observed in further haplotype analysis (P>0.05). In a meta-analysis of ACE gene insertion-deletion (I/D) polymorphism from six studies with 1183 lung cancer patients and 1065 controls, we failed to detect any significant association (overall OR=1.09; 95% CI: 0.84-1.41). A low probability of publication bias was observed. CONCLUSIONS: Our results suggest that ACE gene A-240T polymorphism might be a genetic marker for the development of lung cancer in Chinese people.
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Gao et al. (2012) conducted a case-control in Lung cancer (n=1,286). ACE gene A-240T allele vs. Non-carriers was evaluated on Lung cancer risk (OR 1.2, 95% CI 1.02-1.42, p=0.027). Carriers of the ACE gene A-240T allele had a significantly increased risk of lung cancer under an additive model (OR 1.2; 95% CI 1.02-1.42; P=0.027).
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