Effects of Some Metabolic Analogs on Growth of Mumps and Influenza Viruses in Tissue Cultures.

The vitamin analogs oxythiamine and desoxypyridoxine inhibit the multi plication of mumps and influenza (PR8) viruses in tissue cultures at concentrations shown to be without observable toxic effects on the tissue itself. Other analogs tested, including pyridine-3-sulfonic acid, salicyl-β-alanide, 2-amino-4-hydroxy-6-formylpterine, 2,6-diaminopurine, 8-azaguanine, and β-2-thienylalanine, demonstrated no significant inhibitory effects on the growth of these viruses under the conditions of these experiments.