Impact of gender: Rivaroxaban for patients with atrial fibrillation in the XANTUS real‐world prospective study

Figures

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  FIGURE 1. Adjusted outcomes by gender*Adjusted for age, first available CrCl, CHF, uncontrolled hypertension, prior stroke/TIA/nonCNS SE, prior bleeding, vascular disease, liver disease and baseline antiplatelets/acetylsalicylic acid/nonsteroidal anti‐inflammatory drugs; †adjusted for age, first available CrCl, CHF, hypertension, prior stroke/TIA/nonCNS SE, vascular disease and diabetes mellitus; ‡adjusted for age, first available CrCl, CHF, hypertension, prior stroke/TIA/nonCNS SE, vascular disease, diabetes mellitus and current smoker; §adjusted for age, first available CrCl, CHF, hypertension, prior bleeding, prior stroke/TIA/nonCNS SE, vascular disease, diabetes mellitus, current smoker, baseline antiplatelets/acetylsalicylic acid/nonsteroidal anti‐inflammatory drugs and liver disease; ¶adjusted for age, hypertension, vascular disease, diabetes mellitus and current smoker aHR, adjusted hazard ratio (men vs women); CHF, congestive heart failure; CI, confidence interval; CrCl, creatinine clearance; HR, hazard ratio; nonCNS SE, noncentral nervous system systemic embolism; TIA, transient ischemic attack

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  FIGURE 2. Influence of risk factors on major bleeding by gender *P value is based on the interaction between gender and the individual risk factor. ASA, acetylsalicylic acid; CI, confidence interval; CrCl, creatinine clearance; HR, hazard ratio; nonCNS SE, noncentral nervous system systemic embolism; NSAID, nonsteroidal anti‐inflammatory drug; TIA, transient ischemic attack

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  FIGURE 3. Influence of risk factors on A, stroke/nonCNS SE by gender and B, all‐cause death by gender*P value is based on the interaction between gender and the individual risk factor. CI, confidence interval; CrCl, creatinine clearance; HR, hazard ratio; nonCNS SE, noncentral nervous system systemic embolism; TIA, transient ischemic attack

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  FIGURE 4. Influence of risk factors on the composite outcome of major bleeding, all‐cause death, stroke or nonCNS SE by gender *P value is based on the interaction between gender and the individual risk factor. ASA, acetylsalicylic acid; CI, confidence interval; CrCl, creatinine clearance; HR, hazard ratio; nonCNS SE, noncentral nervous system systemic embolism; NSAID, nonsteroidal anti‐inflammatory drug; TIA, transient ischemic attack