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The study evaluated the effect of Saponins from Tithonia diversifolia leaf on lipid profile of normal rats. 35 rats were divided into six groups of five animals each. Group 1 served as control while groups 2-6 were administered 20, 40, 60, 80 and 100 mg/kg of Saponins from Tithonia diversifolia leaf for 21 days. Results indicated that administration of Saponins significantly reduced (p<0.05). Triglyceride (TG), Total Cholesterol (TC) and Low Density Lipoprotein (LDL) and increased the level of High Density Lipoprotein (HDL). These results suggest that Saponins from T. diversifolia leaf can prevent serum TG and cholesterol which are risk factors of coronary heart disease. Further studies at the molecular level are needed to understand the mechanism.
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Olalekan et al. (2022) studied this question.
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