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To many people it is unfathomable that after more than 10 years of research, there is no human immunodeficiency virus (HIV) vaccine ready for large-scale efficacy trials. A complex web of scientific, political, and social issues remains to be untangled. Barry Bloom (Howard Hughes Medical Institute, Albert Einstein College of Medicine, USA) takes a hard look at the fundamental questions that must be answered before a vaccine against acquired immunodeficiency syndrome (AIDS) becomes a reality.
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Barry R. Bloom (1996) studied this question.
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