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Statistical estimation theory is applied to the problem of analyzing data obtained in dynamic tracer studies in nuclear medicine. Procedures are given for the determination of the maximum likelihood (ML), maximum a posteriori probability (MAP), and minimum meansquare-error (MMSE) estimates of parameters describing the transport of the monitored tracer in tissue. Some numerical results are given for data obtained in monitoring the natural decay of strontium-85 and oxygen-15 isotopes frequently used in nuclear medicine.
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Donald L. Snyder (1973) studied this question.
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