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Most patients with chronic myelocytic leukaemia (12 cases in this material) excreted much larger quantities (up to twenty times normal) of histamine metabolites in the urine than healthy individuals and patients with other forms of leukaemia. This indicated an increased rate of formation of histamine in chronic myelocytic leukaemia. The site and mechanism of this increased histamine formation is discussed in relation the metabolic pattern found.
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Berg et al. (1971) studied this question.
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