Abobotulinum toxin A and fillers for facial rejuvenation: My experience and technique

AboTA was approved by US FDA in 2009 for moderate-tosevere glabellar lines [4].In Russian countries the on label indication, supported by Ipsen Company is the upper third of the face.All other indications are based on personal experience of different authors [5].Even if it is not totally confirmed by the literature, AboTA has a greater diffusion confirmed in my clinical practice and my conversion ratio is quit always 2.5U Dysport: 1U Botox.A greater conversion ratio 3:1 in my opinion leads to more side effects, confirmed also by many studies [6].Dilution of AboTA is another discussed task.Quit 13 years ago I already published my philosophy of a very low dilution [7] to reduce spreading and nowadays the best dilution in my opinion remains around 2.5 ml of normal saline for 500U.But in many indications I dilute around 3 ml, while sometimes I prefer to reduce diffusion reducing dilution also up to 1.5 ml.Fillers discussed in this publication are produced by Filorga, XHa3, Volume and MHa18.Also new range of fillers, Art Fillers Volume, Lips, Universal and fine lines have been discussed and remain in the opinionIn the formulations of BTxA there are also some nontoxic accessory proteins (NAPs) joined to the 150-kD active chain.