No association of the SNP rs1048261 within 3'UTR of HSPB7 with cardiovascular morbidity in patients with psoriasis; a possible effect on miRNA-mediated translational regulation

Background: Previous studies have shown an increased risk of cardiovascular diseases in patients with psoriasis. It has also been known that abnormal levels of microRNA (miRNA) contribute to the pathogenesis of psoriasis and its comorbidities. Moreover, single nucleotide polymorphisms (SNPs) within miRNA genes or 3'UTR of the miRNA target genes can alter gene expression and thus contribute to the pathogenesis of the disease.