Topical non-steroidal anti-inflammatory drugs: a review of their use and toxicity

This article reviews the range of topical non-steroidal anti-inflammatory drugs available in the UK. These preparations are generally well tolerated and have proved to be efficacious in arthritis and soft tissue injuries with a much reduced risk of adverse effects compared to their systemic counterparts. Their role in dermatological disease remains less clear. Established side-effects include local irritation with erythema or dermatitis, and urticarial reactions can occur with all preparations. Photocontact dermatitis is also well recognized especially with ketoprofen and benzy-damine. Systemic reactions, particularly gastrointestinal disturbance and asthma, occur occasionally.