What question did this study set out to answer?

To investigate the physiological, biochemical, and lipidomic adaptive mechanisms of the green microalga Chlamydomonas reinhardtii during exposure to toxic cadmium concentrations.

July 9, 2026Biotechnology ReportsOpen Access

Adaptive responses of Chlamydomonas reinhardtii to cadmium stress: physiological, biochemical, and lipidomic insights

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Authors

MAMohammad Aadil NSNihad Sahri CMChanda MutaleJoan

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Overview

Experimental study reveals lipid and metabolic remodeling in Chlamydomonas reinhardtii under cadmium toxicity, highlighting coordinated antioxidant and membrane adaptations.

Key Points

To investigate the physiological, biochemical, and lipidomic adaptive mechanisms of the green microalga Chlamydomonas reinhardtii during exposure to toxic cadmium concentrations.
Exposed Chlamydomonas reinhardtii cultures to an EC50 concentration of cadmium (20 ppm) for 8 days.
Quantified oxidative stress indicators, biochemical composition, and antioxidant capacity using DPPH radical-scavenging assays.
Profiled lipid composition via GC-MS and identified metabolic disruptions using KEGG pathway enrichment analysis.
Cadmium exposure elevated hydrogen peroxide by 69%, malondialdehyde by 336%, and proline by 144%, alongside a 50% decrease in DPPH IC50 value.
Total carbohydrates increased by 21.7% and lipids increased by 14%, whereas total protein fell by 39.5% and photosynthetic pigments declined by 44%.
Lipidomic profiling showed depleted unsaturated fatty acids and accumulation of lipid-derived aldehydes and saturated hydrocarbons, enriched in fatty acid biosynthesis, elongation, and glutathione metabolism pathways.

Cite This Study

Aadil et al. (2026) studied this question.

synapsesocial.com/papers/6a9128dca746da0776b391c3 https://doi.org/10.1016/j.btre.2026.e00970

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July 9, 2026Biotechnology ReportsOpen Access

Adaptive responses of Chlamydomonas reinhardtii to cadmium stress: physiological, biochemical, and lipidomic insights

View Full Paper

Ask AI

Bookmark

Authors

MAMohammad Aadil NSNihad Sahri CMChanda MutaleJoan

Discussion

Member takes

Overview

Experimental study reveals lipid and metabolic remodeling in Chlamydomonas reinhardtii under cadmium toxicity, highlighting coordinated antioxidant and membrane adaptations.

Key Points

To investigate the physiological, biochemical, and lipidomic adaptive mechanisms of the green microalga Chlamydomonas reinhardtii during exposure to toxic cadmium concentrations.
Exposed Chlamydomonas reinhardtii cultures to an EC50 concentration of cadmium (20 ppm) for 8 days.
Quantified oxidative stress indicators, biochemical composition, and antioxidant capacity using DPPH radical-scavenging assays.
Profiled lipid composition via GC-MS and identified metabolic disruptions using KEGG pathway enrichment analysis.
Cadmium exposure elevated hydrogen peroxide by 69%, malondialdehyde by 336%, and proline by 144%, alongside a 50% decrease in DPPH IC50 value.
Total carbohydrates increased by 21.7% and lipids increased by 14%, whereas total protein fell by 39.5% and photosynthetic pigments declined by 44%.
Lipidomic profiling showed depleted unsaturated fatty acids and accumulation of lipid-derived aldehydes and saturated hydrocarbons, enriched in fatty acid biosynthesis, elongation, and glutathione metabolism pathways.

Cite This Study

Aadil et al. (2026) studied this question.

synapsesocial.com/papers/6a9128dca746da0776b391c3 https://doi.org/10.1016/j.btre.2026.e00970

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