Dissolution of Sulphamethoxazole From Polyethlene Gylcols and Polyvinlpyrrolidone Solid Dispersions

Solid dispersions of sulphamethoxazole have been prepared by fusion and solvent methods using polyethylens glycols 6000 and 9000, and polyvinylpyrrolidone (mol.wt. 40,000) as water-soluble carriers. Coprecipitates with the latter were superior to other carriers in releasing the drug into solution. Melts with the solvent method. Solubility of the drug increased also with the former produced faster rates of dissolution of sulphamethoxazole than the coprecipitate from the solvent method. Solubility of the drug increased also with corresponding increase in the concetrations of these carriers.