Preparation and Properties of Tablets Prepared from Furosemide-PVP Solid Dispersion Systems

AbstractTablets were prepared from the solid dispersion of furosemide: PVP by using different techniques such as direct compression and double compression. The results were compared with similar tablets prepared by physical mixture. Direct compression was much prefered, as it provided tablets with acceptable mechanical and physical qualities. On the other hand, the choice of disintegrant is very important in the formulation of furosemide: PVP solid dispersed tablets. With Kollidon CL, the best result was obtained. Disintegration mechanism of this system was also discussed. The other effective factor is the particle sizes of coprecipitates. Fine particle exhibited compression difficulty. The drug release from these tablets was 17 times greater than that from tablets prepared from physical mixture.