Animal data link AP phase 2 duration to contractility; leaves open translation to human electromechanical or arrhythmic mechanisms.
Studies of canine and frog myocardium disclose a consistent inverse relation between interval-dependent contractile alterations and the duration of phase 2 of the concomitant action potentials (AP). This is true despite the differing temporal patterns of contractile change in the two species. A relation of both the inotropic state and AP configuration to K+ flux is suggested.
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Edmands et al. (1968) studied this question.
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