Why the study?
Does nicotine affect cardiac muscle contractions and radiocalcium movement in toad ventricular muscle?
Does nicotine affect cardiac muscle contractions and radiocalcium movement in toad ventricular muscle?
Nicotine affects the contractile response of cardiac muscle, likely related to the mobilization of calcium.
Nicotine effects on toad cardiac calcium handling are hypothesis-generating; leaves open any mammalian or clinical relevance.
Nicotine, 0.01–0.1 mm, evoked a positive inotropic response and abolished the "staircase" and poststimulation potentiation in toad ventricular muscle; 0.2 mm nicotine caused the development of contracture, whether or not extracellular Ca++ was present; and 1.0 mm nicotine enhanced the uptake and release of Ca45 from the muscle. It seems probable that the effect of nicotine on the contractile response of cardiac muscle can be related to the mobilization of Ca++.
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Winifred G. Nayler (1963) studied this question.
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