What question did this study set out to answer?

The study aimed to examine the roles of nicotine sensitive neurones in atrial and ventricular tissues of dogs.

May 1, 1993Cardiovascular Research

Differential cardiac responses induced by nicotine sensitive canine atrial and ventricular neurones

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Population

Anaesthetised open chest dogs

Comparison

Nicotine administered at specific loci of in… vs Control injections of saline into active loci…

Design

Preclinical

Authors

BYBobo YuanSoochow University JAJeffrey L. ArdellElectrophysiology DHDavid A. HopkinsBoston College

Discussion

Member takes

Implication

Intrinsic cardiac neurons interact with central control in dogs; leaves open human autonomic mapping or therapies.

Key Points

The study aimed to examine the roles of nicotine sensitive neurones in atrial and ventricular tissues of dogs.
Conducted in anesthetized open-chest dogs with specific nicotine injections to ganglionated plexi.
Cardiovascular responses were assessed before and after decentralisation.
Responses to nicotine were recorded alongside control saline injections.
Cardiovascular responses were elicited from 41% of atrial and 36% of ventricular loci.
Responses varied, with tachycardia observed in 70% of active atrial sites and bradycardia in others.
Ventricular fibrillation occurred in two animals during ventricular locus investigations.

Structured PICO

Population

Anaesthetised open chest dogs

Intervention

Nicotine (100 micrograms in 0.1 ml 0.9% saline) administered at specific loci of in situ atrial and ventricular ganglionated plexi

Comparator

Control injections of saline (0.1 ml) into active loci; responses before and after decentralisation, atropine, and propranolol

Outcome

Cardiovascular effects (heart rate and atrial/ventricular forces)surrogate

The canine heart contains nicotine-sensitive intrinsic cardiac neurons that can induce augmentor or depressor cardiac effects and interact with central neurons.

Cite This Study

Yuan et al. (1993) studied this question.

synapsesocial.com/papers/6a71765f26a7f98052ddce40 https://doi.org/10.1093/cvr/27.5.760

View Full Paper

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Differential cardiac responses induced by nicotine sensitive canine atrial and ventricular neurones

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Differential cardiac responses induced by nicotine sensitive canine atrial and ventricular neurones

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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