What is the clinical evidence from this study?

Intervention: Intravenous nicotine. Primary outcome: Cardiac arrhythmias.

What question did this study set out to answer?

This study aims to assess the arrhythmogenic activity following acute administration of nicotine in dogs.

December 1, 1997Journal of Cardiovascular Pharmacology and Therapeutics

Cardiac Arrhythmias Following Intravenous Nicotine: Experimental Study in Dogs

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Key result

Intravenous nicotine exhibited dose-dependent arrhythmogenicity in dogs, with 50 µg/kg significantly inducing supraventricular (83%, P<0.0001) and ventricular arrhythmias.

Why the study?

Does intravenous nicotine induce cardiac arrhythmias in anesthetized dogs?

Population

16 anesthetized dogs

Design

Preclinical

Follow-up

30 minutes

Authors

MMMahaveer C. MehtaBauhaus-Universität Weimar AJAbnash C. JainWest Virginia University AMAnurag MehtaGeneral / Preventive / Lipids

Discussion

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Implication

May signal arrhythmia risk with nicotine; leaves open translation of canine data to humans.

Key Points

This study aims to assess the arrhythmogenic activity following acute administration of nicotine in dogs.
Administered various doses of intravenous nicotine to 16 anesthetized dogs.
Conducted 52 experiments with continuous anesthesia and monitoring after nicotine administration.
Electrocardiograms were analyzed at specific time intervals post-administration.
Supraventricular arrhythmias and atrioventricular junctional arrhythmias were significantly induced by a 50 µg/kg dose.
Ventricular arrhythmias, including ventricular tachycardia and flutter, occurred at higher doses with significant metrics (P <.0001).
Higher nicotine doses resulted in fatal ventricular fibrillation, leading to cessation of those experiments.

Structured PICO

Does intravenous nicotine induce cardiac arrhythmias in anesthetized dogs?

Population

16 anesthetized dogs underwent 52 experiments to assess the dose-dependent arrhythmogenic effects of intravenous nicotine.

Intervention

Intravenous nicotine in different doses (2.5, 5.0, 10.0 mg/kg, 50 µg/kg, 100 µg/kg)

Outcome

Cardiac arrhythmias (assessed by ECG at 1, 2, 3, 4, 5, 10, 15, and 30 minutes)surrogate

Intravenous nicotine exhibits dose-dependent arrhythmogenicity in dogs, with higher doses inducing severe and potentially fatal ventricular arrhythmias.

Limitations

Animal study; requires further work in human beings to confirm if cigarette smoke generates similar arrhythmias

Cite This Study

Mehta et al. (1997) studied this question. Intravenous nicotine was evaluated on Cardiac arrhythmias. Intravenous nicotine exhibited dose-dependent arrhythmogenicity in dogs, with 50 µg/kg significantly inducing supraventricular (83%, P<0.0001) and ventricular arrhythmias.

synapsesocial.com/papers/6a6b7bde6f523709a024a6fc https://doi.org/10.1177/107424849700200407

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Cardiac Arrhythmias Following Intravenous Nicotine: Experimental Study in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Cardiac Arrhythmias Following Intravenous Nicotine: Experimental Study in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

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