Why the study?
Does nicotine infusion increase left ventricular stroke volume compared to aortic constriction in anesthetized dogs?
Population
11 anesthetized open-chest dogs
Comparison
Infusion of nicotine (20–25 μg·kg−1·min−1) vs Aortic constriction
Design
Preclinical
Authors
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Nicotine may augment contractility independently of afterload in this canine model; leaves open any human hemodynamic relevance.
Does nicotine infusion increase left ventricular stroke volume compared to aortic constriction in anesthetized dogs?
Nicotine infusion increases stroke volume and myocardial contractility in dogs despite raising aortic blood pressure, unlike aortic constriction which reduces stroke volume.
Ilebekk et al. (1974) studied this question.