Population
Anesthetized, artificially ventilated open-chest dogs
Comparison
2.5–20 µg/kg nicotine injected into the… vs 5-sec control period immediately preceding…
Design
Preclinical
Follow-up
10 seconds (two 5-sec periods post-injection)
Authors
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Adds to models of chemoreflex pulmonary control; leaves open translation from canine data to human physiology or therapy.
Stimulation of aortic body chemoreceptors by nicotine in dogs induces reflex pulmonary vasoconstriction via sympathetic efferent pathways.
Stern et al. (1964) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: