What question did this study set out to answer?

This research aims to assess how stimulation of carotid and aortic body chemoreceptors influences left ventricular inotropic responses in cats.

June 1, 1998The Journal of PhysiologyOpen Access

Respiratory modulation of carotid and aortic body reflex left ventricular inotropic responses in the cat

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Population

Cats anaesthetized with a mixture of chloralose and urethane, artificially ventilated with an open…

Comparison

Selective stimulation of the carotid and aortic… vs Control state and temporary suppression of…

Design

Preclinical

Authors

MDM. de Burgh DalyUniversity of London JJJames F. JonesUniversity College Dublin

Discussion

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Implication

Aortic chemoreceptor inotropy is respiration-independent in cats unlike carotid; extends animal chemoreflex data but leaves open human translation.

Key Points

This research aims to assess how stimulation of carotid and aortic body chemoreceptors influences left ventricular inotropic responses in cats.
Cats were anesthetized and artificially ventilated.
Stimulation of carotid and aortic bodies was performed using sodium cyanide.
Responses were measured as changes in left ventricular dP/dt max under varying respiratory conditions.
Carotid body stimulation caused a significant increase in left ventricular dP/dt max of 8.3 +/- 2.9% from control.
Aortic body stimulation resulted in a larger increase of 19.6 +/- 2.9% from control for left ventricular dP/dt max.
Propranolol administration abolished the positive inotropic responses, indicating sympathetic mediation.

Structured PICO

Population

Cats anaesthetized with a mixture of chloralose and urethane, artificially ventilated with an open pneumothorax

Intervention

Selective stimulation of the carotid and aortic body chemoreceptors by sodium cyanide

Comparator

Control state (baseline) and temporary suppression of secondary respiratory mechanisms

Outcome

Reflex changes in the inotropic state of the left ventricle, measured as the dP/dt max (maximum rate of change of pressure)surrogate

The positive inotropic response to carotid body stimulation is predominantly due to concomitant neurogenic effects of increased respiration, whereas the response to aortic chemoreceptor excitation is not respiratory modulated.

Cite This Study

Daly et al. (1998) studied this question.

synapsesocial.com/papers/6a72c17dfebe604dd70ac1fb https://doi.org/10.1111/j.1469-7793.1998.895bm.x

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Implication

Aortic chemoreceptor inotropy is respiration-independent in cats unlike carotid; extends animal chemoreflex data but leaves open human translation.

Respiratory modulation of carotid and aortic body reflex left ventricular inotropic responses in the cat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Respiratory modulation of carotid and aortic body reflex left ventricular inotropic responses in the cat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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