Reflex cardiac dromotropic responses to stimulation of the carotid and aortic chemoreceptors in the anaesthetized cat

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Population

Anaesthetized cats

Design

Preclinical

Authors

Discussion

Hypothesis-generating for chemoreflex effects on AV conduction; leaves open human translation and clinical relevance.

Population

Anaesthetized cats

Intervention

Selective stimulation of the carotid and aortic bodies by sodium cyanide

Outcome

Reflex changes in the dromotropic state of the heart (P-R interval or atrioventricular conduction time)surrogate

Stimulation of carotid and aortic chemoreceptors in cats increases atrioventricular conduction time primarily via a vagal cholinergic mechanism.

Jones et al. (1997) studied this question.

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