Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1991The Journal of PhysiologyOpen Access

Some reflex cardioinhibitory responses in the cat and their modulation by central inspiratory neuronal activity.

View Full Paper
Ask AI
Bookmark
Share

Key result

Central inspiratory drive reduced carotid chemoreceptor-induced bradycardia to 15% of control, and arterial baroreceptor and cardiac receptor responses to 42% and 51%, but did not affect pulmonary C fibre responses.

Population

Cats anaesthetized with a mixture of chloralose and urethane, artificially ventilated

Comparison

Stimulation of cardiovascular receptors vs Control state

Design

Preclinical

Authors

MDM. de Burgh DalyUniversity of London

Discussion

Loading...

Member takes

Implication

Highlights respiratory gating of select vagal reflexes in cats; leaves open translation to human cardiorespiratory control.

Key Points

  • This research aims to understand how central inspiratory neuronal activity affects cardioinhibitory responses in cats.
  • Cats were anesthetized and artificially ventilated while measuring changes in central inspiratory neuronal activity.
  • Reflex responses were induced by stimulating various cardiovascular receptors using specific injections.
  • Pulse intervals were assessed during inspiratory and expiratory phases, comparing control and stimulated states.
  • Bradycardia from carotid chemoreceptors during expiration reduced to 15% during inspiration.
  • Responses from arterial baroreceptors and cardiac receptors decreased to 42% and 51% respectively during inspiration.
  • Pulmonary C fibre-induced bradycardia was largely unaffected by central inspiratory drive.

Structured PICO

P
Population
Anaesthetized, artificially ventilated cats.
E
Exposure
Stimulation of cardiovascular receptors (carotid body chemoreceptors by cyanide, arterial baroreflex by blood pressure elevation, cardiac receptors by veratridine, and pulmonary C fibres by phenylbiguanide)
C
Comparator
Control state (comparing inspiratory and expiratory phases of the respiratory cycle)
O
Outcome
Reflex cardioinhibitory responses (changes in pulse interval/bradycardia)surrogate

Central inspiratory neuronal activity differentially modulates reflex cardioinhibitory responses depending on the afferent receptor stimulated, primarily via vagal efferents.

Cite This Study

M. de Burgh Daly (1991) studied this question. Central inspiratory neuronal activity vs. Expiratory phase of the respiratory cycle was evaluated on Reflex cardioinhibitory responses (bradycardia) elicited by stimulation of cardiovascular receptors. Central inspiratory drive reduced carotid chemoreceptor-induced bradycardia to 15% of control, and arterial baroreceptor and cardiac receptor responses to 42% and 51%, but did not affect pulmonary C fibre responses.

synapsesocial.com/papers/6a238468412756072fa5dd84https://doi.org/10.1113/jphysiol.1991.sp018682
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Generation and Maintenance of the Respiratory Rhythm1982 · 462 citations
  2. 2Cardiovascular responses to stimulation of pulmonary C fibres in the cat: their modulation by changes in respiration.1988 · 44 citations
  3. 3Synaptic mechanisms involved in the inspiratory modulation of vagal cardio‐inhibitory neurones in the cat.1984 · 262 citations
  4. 4Inspiratory inhibition of vagal responses to baroreceptor and chemoreceptor stimuli in the dog.1981 · 56 citations
  5. 5Baroreceptor inputs to the nucleus tractus solitarius in the cat: postsynaptic actions and the influence of respiration.1988 · 91 citations