Key result
Stimulating intrinsic cardiac neurones triggers ventricular arrhythmias in ~33% of canine models.
Why the study?
The involvement of intrinsic cardiac neurones in the genesis of ventricular arrhythmias was investigated to understand their role in arrhythmogenesis.
Population
57 anaesthetised dogs
Design
Preclinical experimental study with local neurochemical administration
Authors
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May implicate intrinsic cardiac neurons in ventricular arrhythmogenesis; hypothesis-generating in animal models and leaves open human relevance.
p-value: p=<0.05
Chemical modification of intrinsic cardiac neurones can induce ventricular arrhythmias, suggesting a role for the intrinsic cardiac nervous system in arrhythmogenesis.
Huang et al. (1994) studied Ventricular arrhythmias (n=57). Local administration of neurochemicals vs. Baseline / before acute decentralisation was evaluated on Induction of ventricular arrhythmias and change in neuronal activity (p=<0.05). Local administration of neurochemicals to intrinsic cardiac neurones induced ventricular arrhythmias in one third of dogs, with neuronal activity increasing from 0.7 to 2.2 impulses/s (p<0.05).
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